Lipoproteins

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Hepatic Golgi lipoproteins: precursors to plasma lipoproteins in hypercholesterolemic rats.

Two classes of nascent lipoproteins can be isolated from Golgi apparatus-rich fractions of liver from hypercholesterolemic rats. Golgi very low density lipoproteins (VLDL, d less than 1.006 g/ml) are enriched in cholesteryl esters and are similar in many respects to hypercholesterolemic plasma B-VLDL. Golgi low density lipoproteins (LDL, d 1.006-1.05 g/ml) are cholesteryl ester-rich beta-migrat...

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very-low-density lipoproteins

1. Human total HDL (high-density lipoprotein), HDL2 and HDL3 were labelled in vitro by incubation with lipoproteindeficient serum (LPDS) which contained either [3H]cholesteryl oleate or [14C]cholesterol under different conditions. The lipoproteins were then subfractionated by heparin-Sepharose column chromatography, and three subfractions (A, B and C) were successively eluted from each preparat...

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Oxidized Low Density Lipoproteins

The direct vasoactive effects of native and oxidatively modified low density lipoproteins as well as their effects on endothelium-dependent relaxations to 5-hydroxytryptamine were studied in isolated rings of pig right coronary artery. Slowly developing contractions were caused by native low density lipoproteins (100 gg protein/ml). The contractions were more pronounced in the absence than in t...

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Lipoproteins in choline deficiency.

Choline deficiency leads to lipomatous infiltration of the coronary arteries and to aortic sclerosis of the Moenckeberg type in young rats. In this form of experimental cardiovascular disease the total serum cholesterol and the triglyceride-bearing lipoproteins are decreased. The beta-lipoprotein classes are essentially within normal limits. The significance of these findings in particular and ...

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Canine Lipoproteins and Atherosclerosis

Characterization of the hyperlipoproteinemia induced by feeding high-cholesterol diets to hypothyroid dogs was undertaken in an attempt to identify a lipoprotein pattern or a specific lipoprotein responsible for the atherosclerosis associated with such hyperlipoproteinemia. Various degrees of hyperlipidemia and atherosclerosis were produced during the diet, which was imposed for 3 months to mor...

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ژورنال

عنوان ژورنال: Nature

سال: 1949

ISSN: 0028-0836,1476-4687

DOI: 10.1038/1641079a0